Microsoft VBScript runtime error ‘800a0046’ Permission denied

Microsoft VBScript runtime error ‘800a0046’
Permission denied

I recently had this error. Turns out the user running the script did not have write permissions to C:\Inetpub\mailroot\Pickup so the email could never be generated. I used Filemon to find this out: http://technet.microsoft.com/en-us/sysinternals/bb896642.aspx