Exception Details: System.Security.SecurityException: Request for the permission of type ‘System.Web.AspNetHostingPermission, System, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089’ failed. error in DotNetNuke

After fighting with this error for oh, 20 or so minutes, Exception Details: System.Security.SecurityException: Request for the permission of type ‘System.Web.AspNetHostingPermission, System, Version=2.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089’ failed.
the end result was to go into the ApplicaitonPool Advanced Settings in IIS and set Load User Profile to True from False: